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Founded by Deep Science Ventures veterans, Dr Kerstin Papenfuss, CEO and co-founder, and Dr Mark Hammond, CTO and co-founder, Big Picture Bio identifies, designs and optimises promising cancer combination therapies.

To keep pace with electrification, data centres and reshoring, the US needs to build roughly 5,000 miles of new transmission every year.

DSV’s Venture Science Doctorate Scales Global Lab Network to 40

A conversation with Thunderstone CEO Eric Wasson Burns on why the energy transition's metals problem can't be solved by recycling alone and what high-voltage physics has to do with it.

In this episode, Dom Falcão sits down with Luke Tan, Co-Founder and CPO of Supercritical, to discuss how they are intentionally designing a way out of the carbon crisis by reinventing one of the world's most critical commodities, hydrogen.

Announcing a new venture creation initiative with Renaissance Philanthropy, focused on priming resilience in crops as part of our Climate Emergencies Resilience Lab. Our goal is systemic intervention through: Forecast-driven biological priming, environment-responsive microbes and protectants and new breeding tools to unlock resilience traits.

This consortium between Deep Science Ventures, SPRIND and Builder's Vision fully funds five PhDs with total autonomy and research investment to build innovation beyond traditional scientific bottlenecks

In this episode, Kerstin Papenfuss speaks with Aleck Jones, Founder of Kindling Bio, a company developing a new approach to immunotherapy for childhood cancers.

Deeptech from scratch #3. In this, our third episode, we get into it with Neobe Therapeutics. Founded by Pedro Correa de Sampaio and Annelise Soulier, they have set out to dismantle the physical walls of solid tumours using engineered bacteria. To find out how they are using synthetic biology to turn microbes into biological bulldozers that unlock the efficacy of cancer immunotherapies.

The key is building an economy where the rainforest is worth more alive than dead.

Deeptech from scratch #2. We get into it with Dunia. Founded by Ahmed Ismail, Alex Hammer and Marcus Tze-Kiat Ng, they've set out to close the ‘Sim2Real’ gap for catalysts R&D. To find out what this means, you can listen to the full interview with Ahmed

Deeptech from scratch. Dive into the world of Hot Green Solutions. Founded by former consultant Georgia and her co-founder Andrew, they've set out to replace industrial boilers, an innovation that could slash global carbon emissions by 10%.

Is there money to be made in developing emerging technologies which can make our world safer? In this article, we explore the commercial opportunities in creating a toxicity free future.

What if we could save 12 billion lives and $12.5 trillion by 2050? Our new report, "Breaking the Cascade of Climate Risks," details how we can do just that.

We're excited to share our latest report - "The Invisible Tsunami" on environmental toxicity.

Renaissance Philanthropy partners with Deep Science Ventures to identify and develop scalable innovations designed to strengthen global resilience to escalating climate risks

A first-of-its-kind biotech company, CureAge Therapeutics, has officially launched to develop curative therapies for neurofibromatosis type 1 (NF1), a genetic condition affecting over 3 million people worldwide.

The Global Impact Coalition, a leading platform enabling sustainability in the chemical sector have partnered with Deep Science Ventures to accelerate sustainable innovation by uniting the chemical industry’s expertise with a pioneering venture creation model.

Germany’s Federal Agency for Breakthrough Innovation (SPRIND) and Deep Science Ventures (DSV) announce a, first-of-a-kind partnership to drive breakthroughs in Climate and Health sectors by commissioning five Venture Science Doctoral scholars (VSD)

A partnership which combines Deep Science Ventures’ novel first-principles methodology and AI tools, with General Inception’s expertise in advancing early-stage innovations to drive scientific discovery and venture creation

Mark1 will revolutionize project development for critical, capital-intensive climate tech startups

The partnership between Deep Science Ventures and  Alliance of Bioversity International and CIAT (a CGIAR center) will extend the research, supervision and talent attraction capabilities of Deep Science Ventures’ Ph.D. programme (The Venture Science Doctorate).

In this article, we explore how human activity and global warming are causing arable land to disappear at an alarming rate. By intervening and enforcing regenerative cycles instead of exploitive ones, we have the opportunity to create a brighter future for the environment and humanity.

At the current rate of greenhouse gas emissions, we’re on track to exceed a dangerous threshold - 2°C of warming - by 2050. In this article, we consider why methane abatement could help us to avoid near-term warming, and outline potential approaches for venture creation that could make this a reality.

Installed renewables capacity has been exceeding forecasts year on year, but there’s a cloud on the horizon: renewables cannot be on-demand. Or can they? To keep on our trajectory to net-zero emissions power, we need to face the next hurdle: overcoming seasonal intermittency.

We believe there is a significant opportunity to revolutionise the way we treat paediatric cancer patients, by taking a paediatric-first approach.

We announce our alliance with Parkinson's UK.

In this article, we explore the past, present, and future of the CDR industry as we build three new ventures to support the creation and function of this nascent industry.

Enedra Therapeutics, a therapeutics company within the Deep Science Ventures portfolio, announces that it is adding a number of seasoned industry executives as co-founders, bringing extensive expertise in cancer biology, drug discovery and corporate strategy to the team.

Agricultural residues are increasingly no longer seen as waste, but as valuable resources and inputs for other sectors of the economy. While advancements in technology are enabling the transformation of these raw materials into products, we are still failing to harness these resources effectively, with vast amounts of potential feedstocks being wasted or used for low-value applications. In this article, we explore how a commodity market for these materials might help us overcome this problem.

Despite being among the most common genetic disorders worldwide (1 in ~2500 births collectively) the NF field has sadly been overlooked for decades. Yet it is difficult to understand why, given the huge unmet need and extremely limited treatment options – none of which offer curative potential for patients. Gene therapy offers the path towards a cure. In this article, we outline the nature of the challenge, why now is the right time to solve it, and explore the unanswered questions we'd like to address through venture creation.

Soil degradation from intensive farming practices creates an urgent need for regeneration but current erosion prevention solutions have limitations. In this article, we outline a promising alternative, using biodegradable polymers derived from natural sources, which can integrate into the soil while avoiding environmental risks.

The detrimental effects of rising temperatures on crops are felt worldwide, as climate change expedites withering and drives premature ripening of agricultural produce. The repercussions extend beyond the affected crops, wreaking havoc on surrounding plant life and posing severe challenges for agricultural sustainability and profitability. In this article, we outline potential approaches to support farmers in meeting human needs, supporting livelihoods, biodiversity, and the natural processes that sustain life on Earth

Ancient and remarkably versatile, steel is produced in volumes second only to concrete and aggregate globally, making up critical parts of the modern economy including infrastructure, transport and appliances, and resulting in emissions of 3.5bn tonnes of CO2 annually. With steel production forecast to continue to grow, in this article we explore potential approaches to decarbonising this vital industry.

Despite tremendous unmet need, there are still no cures for inflammatory disease. Existing therapies fail for known reasons – yet nobody has thus far created therapeutics that fulfil all the necessary requirements. We need to find ways to turn off the causal upstream sources of inflammation rather than simply mopping up downstream inflammatory signals.

As current projections stand, over 4 billion people will face some form of water scarcity by 2050 - the majority of which will reside in urban centres. Even if ambitious climate and population growth targets are adopted, only about 20% of water scarcity can be mitigated. In this article, we explore methods for how me might overcome this water scarcity.

There's a talent shortage in deep tech. In a world where personalised medicine and abundant clean energy is no longer restricted to the realm of scientific fiction, unless we can inspire more people to acquire a scientific foundation, and move from science into impact, we risk failing to realise that future. In this article, we outline how creating it will require scientists and engineers to take control of their own stories, to encourage others to join them in working on these hard problems.

Solid tumours are the leading cause of cancer deaths globally, with limited options for treatment once the tumours reach a metastatic stage. While immunotherapy has been a promising treatment for many solid cancers, its success rate varies greatly, leaving many patients without treatment options. In this article, we explore why, and how a new therapeutic approach we're developing, could finally enable immunotherapies in solid tumours.

There is an increasing need for sustainable and efficient ways to produce vital resources, from food and fibre to advanced materials like biofuels and bioplastics. In this article, we outline why we're interested in expanding the range of products produced from crops, and how we can create new venture-able opportunities, while supporting the growth of local, regional, and national bioeconomies.

The first generation of direct air capture companies (DAC) suffered from intensive energy requirements and high costs. In this article, we cover how the next generation of DAC companies are overcoming this challenge, what constraints still exist, and how a new venture that we're creating circumvents them.

In this article, we outline how far gene therapies have come since they were first utilised in the early 1990s, how we're planning on using a promising approach to develop a curative therapy for Cystic Fibrosis, and how you can join us to make it a reality.

Using our methodology of venture creation, we're able to uncover novel therapeutics approaches in a disease area, that often haven't previously been considered. In this article, we explain how this works in practice, and how we've worked with two partners, the Children's Tumor Foundation and the Cystic Fibrosis Foundation, to uncover approaches within Neurofibromatosis and Cystic Fibrosis respectively.

We've partnered with AbbVie, a global pharmaceutical company, to create ventures targeting immune-mediated inflammatory diseases. This content post contains the press release detailing the partnership.

Global food production is responsible for 80% of deforestation, 70% of freshwater use and, in drier regions, also leads to desertification. In this article, we outline approaches to reversing this trend, to increase the agricultural productivity of arid desert regions.

Major hurdles still need to be overcome before cell therapies become pillars of modern medicine. In this article, we outline the opportunity for analytical systems that can optimise differentiation methods of pluripotent stem cells and how this will allow us to generate numerous therapeutic products at scale.

If science is the engine of human progress, research is the fuel. To solve some of the biggest challenges and existential threats facing humanity, we need to ensure that our research and talent pipeline is adequately aligned with the outcomes required to solve these problems.

The Founders leading DSV portfolio companies are among the core drivers of our mission to create a future in which the planet and humanity thrive. In this article, we outline the journey that we take with our Founders as they create their companies and as they continue to scale.

In this article, we explain how our Outcomes Graph works, including how the functions of scientific knowledge shape the features we've developed and how we're using it to harness the collective intelligence of venture scientists.

At the centre of our venture creation efforts sit a shared ontology and knowledge graph, a tool we call the Outcomes Graph. In this article, we outline how it works and how it empowers our team and founders to identify the constraints and solutions within an area, to create more effective ventures.

Companies are being left vulnerable to cyber security threats, while cyber insurance providers are simultaneously suffering losses. We outline an approach to fix this, to restructure cyber insurance provision and realign incentives.

Ocean alkalinity enhancement has the potential to draw down carbon dioxide at the gigatonne scale but faces challenges with measurement and verification. We set out the case for an alternative approach, which solves these constraints.

As the environmental costs of traditional construction materials have become more widely recognised, the demand for sustainable alternatives has risen. We discuss potential solutions, from fast-growing wood sources to new market applications.

Biomass is an incredible renewable source of carbon, to reduce fossil fuel dependence and enable a circular bioeconomy. We outline our approaches to developing novel agricultural waste processing technologies, to produce high-value compounds.

Climate change is driving deforestation and habitat loss in frontier areas where agriculture borders areas of high biodiversity. With an initial focus on coffee in the tropics, we investigate potential interventions to prevent this.

Introducing our new venture creation program, the Tropical Agriculture & Bioeconomy Initiative, in partnership with CRUSA Foundation, to create companies in Costa Rica focused on regenerative agriculture.

We've expanded our partnership with Cancer Research UK, to develop curative therapies for cancer patients.

We launched XONAI Computing as a next-generation data platform, to overcome the economic burden that cloud computing has become. We discuss their approach, their recent impressive results and our next area of focus.

What we’ve learnt from 5 years of building deep science companies, and how we’re re-engineering scientific venture creation.

To achieve restorative cultivation outcomes, we need to focus our agriculture venture creation efforts on bioregions: Local programs that can be scaled globally.

From home laboratories to electrochemical-testing-devices-in-a-suitcase, Ryan, cofounder of Parallel Carbon tells us how they're building their direct-air-capture company fully remotely.

The insurance industry is struggling with climate change. Portfolio company Malachite is using socio-urban data to incentivise risk-reducing behaviour, in an approach that might allow insurance to save the planet.

There is an unfounded belief often suggested by commentators that recent advancements have rendered cystic fibrosis (CF) manageable for all patients. We explain why we cannot make the assumption that ‘we are done with CF’.

Having launched Parallel Carbon, a direct-air-capture company, in 2021, a year after she joined DSV. Aranza is also building a family: her daughter was born in the same month as her business! She tells us her story.

We need nature-based solutions to solve climate change: Whether it's enhancing the growth of eukaryotic microorganisms in soil or cultivating seagrass meadows, we explore some of those approaches.

We outline why regenerative agriculture is so crucial to solving the triple planetary crisis of nature and biodiversity loss, climate change and runaway pollution and waste accumulation.